Active compounds in green tea may slow the progression of prostate cancer, according to a new study published in Cancer Prevention Research.
The study, which was conducted at Louisiana State University, also showed that green tea might lower the incidence of prostate cancer in the first place.
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The study is one of the few green tea trials that evaluated biomarkers in order to predict prostate cancer’s progression, said study leader James A. Cardelli, director of basic and translational research in the Feist-Weiller Cancer Center at LSU University Health Sciences Center-Shreveport.
The biomarkers tracked were PSA (prostate specific antigen), HGF (hepatocyte growth factor), and VEGF (vascular endothelial growth factor).
The study, which used compounds of green tea polyphenols in the form of Polyphon E provided by Polyphenon Pharma, involved 26 men ages 41 to 72 who were scheduled for radical prostactectomies. For an average of about 35 days up until the day before surgery, each man took four capsules of Polyphenon E, which was equal to drinking 12 cups of normally brewed green tea.
The researchers found that the green tea compounds significantly reduced serum levels of PSA, HGF, and VEGF, with reductions as great as 30 percent in some patients.
There were few side effects, and other biomarkers were “positively affected,” Cardelli said.
Referring to the LSU study and to a year-long clinical trial in Italy involving green tea polyphenols, Cardelli said, “These studies are just the beginning and a lot of work remains to be done. However, we think that the use of tea polyphenols alone or in combination with other compounds currently used for cancer therapy should be explored as an approach to prevent cancer progression and recurrence.”
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