Question: My father died of Alzheimer’s disease, and I’m worried about my own risk. My wife says I should get tested for the Alzheimer’s gene, but if I find out I have it, what good will it do me? I think it would just make me more stressed out. Are there any benefits to gene testing?
Dr. Amen's Answer:
The E4 version (allele) of the apolipoprotein D gene is the major genetic risk factor for inheriting the late-onset type of Alzheimer’s disease, which usually produces symptoms after the age of 60. Everyone has two apoE genes. If one of them, or worse, two of them, are apoE4, that person’s risk for getting Alzheimer’s disease is significantly increased.
Getting tested for the apoE4 gene is a very personal decision. It can be stressful to discover that the gene is present, however, I think knowing about this risk can be very beneficial. It can make you more proactive about living a brain-healthy life so you can reduce your risk.
If you do have the gene, you will want to avoid environmental factors that further increase your chances for it. For example, you would be well-advised to avoid contact sports or activities that increase the risk for head injuries at all costs, because even minor head injuries increase the risk for AD in vulnerable people.
People with the apoE4 gene also should make it a point to exercise, avoid alcohol, and stay away from diets high in sugar and refined carbohydrates.
Knowing that you have the gene also should prompt you to undergo early screening measures, which can detect AD before any symptoms are evident.
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