Scientists ID Genetic 'On-Off Switch' for Heart Disease

Thursday, 20 Jun 2013 04:05 PM

By Nick Tate

Share:
  Comment  |
   Contact Us  |
  Print  
|  A   A  
  Copy Shortlink
A team of U.S. scientists has identified a genetic "on-off switch" for cardiovascular disease. The affected gene — called CPT1A — makes a liver enzyme that, at low levels, is linked to increased risk factors for heart disease and blood-vessel disorders, say researchers from the University of Alabama at Birmingham.
 
In a report on the discovery, presented at an American Heart Association's scientific online seminar,  the researchers said biomarkers tied to CPT1A could offer doctors a significant new way to identify individuals are greater risk for cardiovascular problems — and prevent them.
 
"Our results open the door to the development of new screening tools and a clearer understanding of the biological mechanisms that underlie heart disease," said Stella Aslibekyan, an assistant professor at the University of Alabama.
 
For the study, the researchers tracked CPT1A’s connection to three well-known biomarkers for cardiovascular disease: low-density lipoproteins ("bad" cholesterol), high triglycerides, and a protein called adiponectin, which is made in fat tissue and helps the body turn food into energy.
 
They examined these biomarkers in 888 patients along with a biochemical process called methylation that can switch off the activity of genes in some people. The results showed that those patients with switched-off CPT1A genes had significantly higher triglycerides and LDL cholesterol levels, and less-healthy levels of adiponectin.
 
"This is one step on the road to personalized medicine," Aslibekyan said. "In the future, we may be able to screen for methylation of CPT1A to identify at-risk individuals."
The study was funded by the National Institutes of Health.

© 2014 NewsmaxHealth. All rights reserved.

Share:
  Comment  |
   Contact Us  |
  Print  
  Copy Shortlink
Around the Web
Comments
Please review Community Guidelines before posting a comment.
>> Register to share your comments with the community.
>> Login if you are already a member.
blog comments powered by Disqus
 
Email:
Country
Zip Code:
Privacy: We never share your email.
 
Find Your Condition
You May Also Like
Around the Web
Most Commented

The information presented on this website is not intended as specific medical advice and is not a substitute for professional medical treatment or diagnosis. Read Newsmax Terms and Conditions of Service.

Newsmax, Moneynews, and Independent. American. are registered trademarks of Newsmax Media, Inc. Newsmax TV, NewsmaxWorld, NewsmaxHealth, are trademarks of Newsmax Media, Inc.

NEWSMAXHEALTH.COM
© Newsmax Media, Inc.
All Rights Reserved
> >