New Drug Reduces Heart Damage

Monday, 11 Mar 2013 12:26 PM

 

Share:
A    A   |
   Email Us   |
   Print   |
   Forward Article  |
  Copy Shortlink
A single dose of an experimental anti-inflammatory treatment reduces heart muscle damage during an angioplasty operation to open blocked arteries, a study found Sunday.
 
The antibody inclacumab, developed by Swiss lab Hoffmann-La Roche, significantly reduced levels of the standard molecular markers troponin I and CK-MB in patients, compared to those who took a placebo in a clinical trial.
 
Patients who received the inclacumab dose saw troponin I levels drop 22.4 percent more after 16 hours and 24.4 percent after more at 24 hours (p=0.05), compared with patients on a placebo.
 
CK-MB levels dropped 16.3 percent more after 16 hours and 17.4 percent more at 24 hours, compared with patients on placebo.
 
"It was exciting to see that a single administration of inclacumab would yield clinical benefit," said the study's lead investigator Jean-Claude Tardif, director of the Research Center at the Montreal Heart Institute.
 
The phase II trial examined 530 patients with a median age of 61 experiencing a type of heart attack called non-ST-elevation myocardial infarction or NSTEMI.
 
Patients were randomized to receive an infusion of inclacumab of 20 milligrams per kilogram, five milligrams per kilogram or a placebo one hour before angioplasty.
 
The researchers also found that 24 hours after angioplasty, 18.3 percent of patients on the placebo had CK-MB increases more than three times the upper limit of normal.
 
Many clinical trials define that threshold as the onset of a post-angioplasty heart attack.
But only 8.9 percent of patients who received the higher dose of inclacumab experienced those same CK-MB increases.
 
"If we're able to confirm these results in potential future studies, this drug could become part of the therapeutic armamentarium in modern cardiology," Tardif said in a statement.
"You could use this drug more widely, in all patients coming in with heart attacks, although that would require additional large studies."
 
More than a million coronary angioplasty procedures are performed in the United States each year, costing more than $10 billion.
 
Angioplasty can damage heart tissue, which can trigger a need for more procedures, poor outcomes and higher health care costs .
 
During angioplasty, surgeons insert a balloon catheter to mechanically widen narrowed or obstructed arteries.
 

© AFP 2014

Share:
   Email Us   |
   Print   |
   Forward Article  |
  Copy Shortlink
Around the Web
Comments
>> Register to share your comments with the community.
>> Login if you are already a member.
blog comments powered by Disqus
 
Email:
Retype Email:
Country
Zip Code:
 
Find Your Condition
You May Also Like
Around the Web

The information presented on this website is not intended as specific medical advice and is not a substitute for professional medical treatment or diagnosis. Read Newsmax Terms and Conditions of Service.

Newsmax, Moneynews, and Independent. American. are registered trademarks of Newsmax Media, Inc. Newsmax TV, NewsmaxWorld, NewsmaxHealth, are trademarks of Newsmax Media, Inc.

NEWSMAXHEALTH.COM
© Newsmax Media, Inc.
All Rights Reserved