Tags: belly | fat | gene | weight | loss

Scientists ID Belly Fat Genes

Thursday, 23 Jan 2014 04:09 PM

 

  Comment  |
   Contact  |
  Print   |
    A   A  
  Copy Shortlink
Researchers who identified five new genes linked to belly fat say their findings could help efforts to develop medicines to treat obesity or obesity-related diseases such as heart disease, diabetes, and cancer.
 
The investigators looked at more than 57,000 people of European descent and searched for genes associated with abdominal fat, independent of overall obesity. They examined more than 50,000 variants in 2,000 genes.
 
The team pinpointed three new genes associated with increased waist-to-hip ratio in both women and men, and identified two other genes that appear to affect waist-to-hip ratio in women only. Waist-to-hip ratio is used to measure a person's belly fat. It's believed that genetics account for 30 percent to 60 percent of waist-to-hip ratio.
 
Abdominal fat is a predictor of obesity-related disease, according to the U.S. Centers for Disease Control and Prevention.
 
The new study found that of the two genes that only seem to affect women, one called SHC1 appears to interact with 17 other proteins known to play a role in obesity. SHC1 has been found to be highly active in fat tissue.
 
"This is the first time SHC1 has been associated with abdominal fat," study author Kira Taylor, an assistant professor at the University of Louisville School of Public Health and Information Sciences, said in a university news release.
 
"We believe this discovery holds great opportunity for medicinal chemistry and eventually, personalized medicine," Taylor said. "If scientists can find a way to fine-tune the [activity] of this gene, we could potentially reduce the risk of excessive fat in the mid-section and its consequences, such as cardiovascular disease."
 
The study was recently published online in the journal Human Molecular Genetics.
 
Previous research has found that mice without the SHC1 protein are leaner than those with the protein, the news release noted.

© HealthDay

  Comment  |
   Contact  |
  Print   |
  Copy Shortlink
Around the Web
Comments
Please review Community Guidelines before posting a comment.
>> Register to share your comments with the community.
>> Login if you are already a member.
blog comments powered by Disqus
 
Email:
Country
Zip Code:
Privacy: We never share your email.
 
Find Your Condition
You May Also Like
Around the Web
Most Commented

The information presented on this website is not intended as specific medical advice and is not a substitute for professional medical treatment or diagnosis. Read Newsmax Terms and Conditions of Service.

Newsmax, Moneynews, Newsmax Health, and Independent. American. are registered trademarks of Newsmax Media, Inc. Newsmax TV, and Newsmax World are trademarks of Newsmax Media, Inc.

NEWSMAXHEALTH.COM
© Newsmax Media, Inc.
All Rights Reserved
> >