Scientists: Gene Therapy Cures Diabetes in Dogs

Monday, 11 Feb 2013 12:22 PM

By Nick Tate

Share:
  Comment  |
   Contact Us  |
  Print  
|  A   A  
  Copy Shortlink
Spanish scientists have successfully cured type 1 diabetes in dogs with a single session of gene therapy that they said holds promise for one day treating human patients.

The advance, developed by researchers from the Universitat Autònoma de Barcelona, represents the first time the disease has been cured in large animals, marking a fundamental step toward applying the therapy in humans.

The technique, detailed in the journal Diabetes, involves introducing a "glucose sensor" into the dogs' leg muscles, allowing them to recover from the disease and remain symptom free. In some cases, the dogs appeared completely cured, with no recurrence of diabetes after four years.

Special: These 5 Things Flush 40 lbs. of Fat Out of Your Body.

"This study is the first to demonstrate a long-term cure for diabetes in a large animal model using gene therapy," said lead researcher Fàtima Bosch.

The therapy involves a single session of various injections into the animal's rear legs of a gene therapy agent designed to regulate uptake of glucose from the blood, which reduces hyperglycemia — the excess of blood sugar associated with diabetes. Dogs treated with the therapy showed good glucose control, both when fasting and when fed, with no episodes of hypoglycemia.

Past research by Bosch’s team tested the therapy on mice, but the success of the approach in large animals opens the door to clinical trials of the gene therapy in human diabetic patients.

Diabetes mellitus is the most common metabolic disease, and many patients require insulin injections two to three times a day. Despite treatment, diabetics often develop serious complications like blindness and kidney damage.

© 2014 NewsmaxHealth. All rights reserved.

Share:
  Comment  |
   Contact Us  |
  Print  
  Copy Shortlink
Around the Web
Comments
>> Register to share your comments with the community.
>> Login if you are already a member.
blog comments powered by Disqus
 
Email:
Retype Email:
Country
Zip Code:
 
Find Your Condition
You May Also Like
Around the Web

The information presented on this website is not intended as specific medical advice and is not a substitute for professional medical treatment or diagnosis. Read Newsmax Terms and Conditions of Service.

Newsmax, Moneynews, and Independent. American. are registered trademarks of Newsmax Media, Inc. Newsmax TV, NewsmaxWorld, NewsmaxHealth, are trademarks of Newsmax Media, Inc.

NEWSMAXHEALTH.COM
© Newsmax Media, Inc.
All Rights Reserved